Plant-Based Diet Helps Reduce Premature Aging and Disease Risk
posted 9/16/08
http://www.pcrm.org/news/archive080916.html
In a study released today by The Lancet Oncology, Dean Ornish, M.D., and colleagues found that comprehensive lifestyle changes, including a low-fat vegan diet, increase the body’s ability to fight premature aging, cancer, heart disease, and other chronic diseases.
Twenty-four men participating in a prostate cancer study switched to a plant-based diet and added daily exercise and relaxation techniques. Among other beneficial effects that were previously reported, the intervention led to increased levels of telomerase, an enzyme that protects and repairs DNA. Blood levels of telomerase increased by an average of 29 percent during the study.
Ornish D, Lin J, Daubenmier J, et al. Increased telomerase activity and comprehensive lifestyle changes: a pilot study. Lancet Oncol [advance online publication]. September 16, 2008; DOI 10.1016/S1470-2045(08)70234-1.
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Increased telomerase activity and comprehensive lifestyle changes: a pilot study
a e
, b ‡, a ‡, e, c, e, d, e, e, d and b
‡These authors contributed equally
http://www.thelancet.com/journals/lanonc/article/PIIS1470204508702341/abstract?isEOP=true
Summary
Telomeres are protective DNA–protein complexes at the end of linear chromosomes that promote chromosomal stability. Telomere shortness in human beings is emerging as a prognostic marker of disease risk, progression, and premature mortality in many types of cancer, including breast, prostate, colorectal, bladder, head and neck, lung, and renal cell. Telomere shortening is counteracted by the cellular enzyme telomerase. Lifestyle factors known to promote cancer and cardiovascular disease might also adversely affect telomerase function. However, previous studies have not addressed whether improvements in nutrition and lifestyle are associated with increases in telomerase activity. We aimed to assess whether 3 months of intensive lifestyle changes increased telomerase activity in peripheral blood mononuclear cells (PBMC).
30 men with biopsy-diagnosed low-risk prostate cancer were asked to make comprehensive lifestyle changes. The primary endpoint was telomerase enzymatic activity per viable cell, measured at baseline and after 3 months. 24 patients had sufficient PBMCs needed for longitudinal analysis. This study is registered on the ClinicalTrials.gov website, number NCT00739791.
PBMC telomerase activity expressed as natural logarithms increased from 2·00 (SD 0·44) to 2·22 (SD 0·49; p=0·031). Raw values of telomerase increased from 8·05 (SD 3·50) standard arbitrary units to 10·38 (SD 6·01) standard arbitrary units. The increases in telomerase activity were significantly associated with decreases in low-density lipoprotein (LDL) cholesterol (r=−0·36, p=0·041) and decreases in psychological distress (r=−0·35, p=0·047).
Comprehensive lifestyle changes significantly increase telomerase activity and consequently telomere maintenance capacity in human immune-system cells. Given this finding and the pilot nature of this study, we report these increases in telomerase activity as a significant association rather than inferring causation. Larger randomised controlled trials are warranted to confirm the findings of this study.
US Department of Defense (US Army Medical Research Acquisition Activity W81XWH-05-1-0375, Fort Detrick, Frederick, MD, USA); Henry M Jackson Foundation for the Advancement of Military Medicine (contract 56422; Rockville MD, USA) from the National Center for Complementary and Alternative Medicine (NCCAM) of the National Institutes of Health (grant number K01AT004199; Bethesda, MD, USA); Bahna Foundation (Stamford, CT, USA); DeJoria Foundation (Los Angeles, CA, USA); Kerzner Foundation (New York, NY, USA); Bernard Osher Foundation (San Francisco, CA, USA); Walton Family Foundation (Bentonville, AK, USA); Jeff Walker Family Foundation (Wilton, CT, USA); Safeway Foundation (Pleasanton, CA, USA).
a. Department of Medicine, University of California, San Francisco, CA, USA
b. Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA
c. Department of Psychiatry, University of California, San Francisco, CA, USA
d. Department of Urology, The Helen Diller Family Comprehensive Cancer Center, School of Medicine, University of California, San Francisco, CA, USA
e. Preventive Medicine Research Institute, Sausalito, CA, USA
Correspondence to: Prof Dean Ornish, Preventive Medicine Research Insitute, Sausalito, CA 94965, USA
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